Signal transduction serine/threonine kinases

Sorafenib is a multitargeted cancer therapy that inhibits VEGFR, PDGFR, KIT, fetal liver tyrosine kinase 3 (FLT-3), and the serine/threonine kinase RAF. RAF kinase is a key downstream effector of Ras in the MAPK/Ras signal-transduction pathway that has been linked to various cancers. Sorafenib is both a tyrosine kinase inhibitor and serine/threonine signal-transduction inhibitor. Sorafenib has been approved in renal cancer. 

RING finger proteins may have other domains associated with signal transduction, such as SH3 and STAT domains and domains that bind and effect hydrolysis of nucleotides in signal transduction or for other purposes. These include ATPases, ATP synthases, serine/threonine kinases, GTP-binding domains, ADP-ribosylation domains and AAA-superfamily ATPases (http //home.cancer.gov/lpds/weissman). 

The protein kinases are a family of proteins (serine/threonine kinases and tyrosine kinases) involved in signal transduction. Signal transduction via these proteins occurs through selective and reversible phosphorylation of... 

The protein kinase C (PKC) enzyme family plays a pivotal role in the signal transduction pathways of hormones, neurotransmitters and other endogenous substances. The 11 PKC isoenzymes identified are involved in the activation of many cellular functions. PKCs possess a C-terminal catalytic region with a serine/threonine kinase function and N-terminal regulatory region. The regulatory region is... 

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