Signal transduction ATPases

RING finger proteins may have other domains associated with signal transduction, such as SH3 and STAT domains and domains that bind and effect hydrolysis of nucleotides in signal transduction or for other purposes. These include ATPases, ATP synthases, serine/threonine kinases, GTP-binding domains, ADP-ribosylation domains and AAA-superfamily ATPases (http //home.cancer.gov/lpds/weissman). 

Beltowski J, Marciniak A, Wojcicka G, Gomy D. The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+, K+-ATPase activity. J. Physiol. Pharmacol. 2002 53 211 231. 

Cells carefully control the homeostasis of their ion concentrations by the action of ion channels (Na, K , Ca " channels) and throu Na, K -ATPase and Ca -ATPase. These channels and pumps are involved in signal transduction, active transport processes, and neuronal and neuromuscular signaling. Inhibition of transport processes (ion channels, carriers) is achieved by (Table IV) acronycine, ervatamine, harmaline, quinine, reserpine, colchicine, nitidine, salsolinol, sanguinarine, stepholidine, caffeine, sparteine, monocrotaline, steroidal alkaloids, aconitine, capsaicine, cassaine, maitoxin, ochratoxin, palytoxin, pumiliotoxin, saxitoxin, sole-nopsine, and tetrodotoxin. 

Xie Z, Cai T (2003) Na -K -ATPase-mediated signal transduction liom protein interaction to cellular function. Mol Intrav 3 157-168... 

Xie, Z., Molecular mechanisms of Na/K-ATPase-mediated signal transduction, Ann. NY Acad. Sci. 986, 497, 2003. 

---