Sickle-cell anemia pathophysiology

FIGURE 65-1. Sickle gene inheritance scheme for both parents with sickle cell trait (SCT). A, normal hemoglobin S, sickle hemoglobin. Possibilities with each pregnancy 25% normal (AA) 50% SCT (AS) 25% sickle cell anemia (SS). (From Chan CYJ, Moore R. Sickle cell disease. In DiPiro JT, Talbert RL, Yee GC, et al, (eds.) Pharmacotherapy A Pathophysiologic Approach. 6th ed. New York McGraw-Hill 2005 1856.)... 

Fig. 11.1 Pathophysiologic scheme of sickle cell anemia (see color plates, p. XXXIV).

De long PE, Statius van Eps LW. Sickle cell nephropathy new insights into its pathophysiology. Kidney Int 1985 27 711-719. Allen M, Lawson L, Eckman IR, Delaney V, Bourke E. Effects of nonsteroidal anti-inflammatory drugs on renal function in sickle cell anemia. Kidney Int 1988 34 500-506. 

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