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Sialylated trisaccharides, synthesis determination

The first enzyme we evaluated for its ability to transfer unnatural sugars was the human Lewis a(l- 4)fucosyltransferase (FucT). This particular enzyme was chosen because of its potential utility in the synthesis of the tumor associate sialyl-Lewis-a antigen Q2) <1 analogs thereof. In addition, the enzyme could be quite readily obtained in a soluble form with high specific activity from human milk. The a(l- 4)FucT catalyzes reaction I below which results in the production of the Lewis-a trisaccharide determinant... [Pg.40]

See other pages where Sialylated trisaccharides, synthesis determination is mentioned: [Pg.430]    [Pg.222]    [Pg.222]    [Pg.284]    [Pg.313]    [Pg.396]    [Pg.307]    [Pg.31]    [Pg.327]    [Pg.243]    [Pg.26]   
See also in sourсe #XX -- [ Pg.86 , Pg.88 ]



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