Sialyl Lewis biology

A. Giannis, The sialyl Lewis group and its analogues as ligands for selectins Chemoenzymatic syntheses and biological functions, Angew. Chem. Int. Ed. Engl. 55 178 (1994). 

Huang, H, Wong, C-H, Synthesis of biologically active sialyl Lewis mimetics, J. Org. Chem., 60, 3100-3106, 1995. 

Kretzschmar, G, Toepfer, A, Hiils, C, Krause, M, Pitfalls in the synthesis and biological evaluation of sialyl Lewis mimetics as potential selectin antagonists. Tetrahedron, 53, 2485-2494, 1997. 

Glycopeptides serve as target structures in the investigation of a variety of other biological events. For example, peptides presenting sialyl Lewis x (sLe ) may act as inhibitors of excessive leukocyte extravasation in the inflammatory response [193]. 

Many carbohydrate-binding proteins discriminate between potential ligands through Coulombic interactions. Certain biologically important saccharides, such as sialyl Lewis, other... 

C.M. Huwe, T.J. Woltering, J. Jiricek, G. Weitz-Schmidt, C.-H. Wong, Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis-X mimetics prepared via cross-metathesis of C-fucopeptides, Bioorg. Med. Chem. 1999, 7, 773-788. 

The Sialyl Lewis Group and its Analogues as Ligands for Selectins Chemoenzymatic Synthesis and Biological Functions... 

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