Sialoconjugates

Scheme 17.1 Major anabolic (solid arrows) and catabolic reaction cascades (dashed arrows) involved in sialoconjugate metabolism.

In this chapter, we review the recent advances in the development of biocatalytic reaction cascades for the synthesis of highly diversified sialoconjugate stmctures that are instrumental for studies in glycobiology and for potential diagnostic and therapeutic applications. 

Table 17.1 Enzymes involved in anabolism and catabolism of sialoconjugates.

Figure 17.2 The three basic forms of sialic acids, and the natural sialic acid diversity of sialoconjugates [4, 12]. The standard nine-carbon sugar backbone common to...

Scheme 17.2 Complementary strategies for the creation of sialoconjugate diversity, (a) Natural divergent strategy of in vivo biosynthetic pathways, based on standard Leloir pathway followed by post-synthetic enzymatic diversification, (b) Universal synthetic...

Scheme 17.3 Structurally modified sialic acids used as synthetic probes for the Leloir-path sialyltransfer enzymes, and toward the preparation of natural sialoconjugates and nonnatural neo-sialoconjugate. (a) Structural variations of NeuSAc. (b) KDN.

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