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Sialidases carboxyl group

Miyatake et al. (1979) reported the use of mass fragmentography in sialidase activity studies. For the analysis of released Neu5Ac, the carboxyl group as well as the various hydroxyl functions were trimethylsilylated. As the internal standard the trimethylsilylated derivative of N-acetylgalactosamine a-phenyl glycoside was... [Pg.122]

The presence of the free carboxyl group in the sialic acid residue is essential for sialidase action (Yu and Ledeen, 1969). The methyl esters of sialic acids in... [Pg.262]

Fig. 8 Superimposition of inhibitors and key active site residues in influenza A virus sialidase cyclopentane-based inhibitor peramivir 34 (brown carbons, PDB - 117f), Neu5Ac2en 4 (green carbons, PDB - lf8b). Note the overlap of the carboxyl and acetamido-methyl groups of the inhibitors, and the alternative conformations of the side-chain of Glu276. To the right is shown peramivir 34 oriented as in the crystal structure... Fig. 8 Superimposition of inhibitors and key active site residues in influenza A virus sialidase cyclopentane-based inhibitor peramivir 34 (brown carbons, PDB - 117f), Neu5Ac2en 4 (green carbons, PDB - lf8b). Note the overlap of the carboxyl and acetamido-methyl groups of the inhibitors, and the alternative conformations of the side-chain of Glu276. To the right is shown peramivir 34 oriented as in the crystal structure...

See other pages where Sialidases carboxyl group is mentioned: [Pg.125]    [Pg.126]    [Pg.127]    [Pg.175]    [Pg.202]    [Pg.204]    [Pg.471]    [Pg.96]    [Pg.464]    [Pg.469]    [Pg.472]    [Pg.133]    [Pg.1784]    [Pg.346]    [Pg.109]    [Pg.111]    [Pg.112]    [Pg.289]    [Pg.330]    [Pg.729]    [Pg.402]    [Pg.403]    [Pg.423]    [Pg.456]    [Pg.664]    [Pg.42]    [Pg.227]    [Pg.263]    [Pg.264]    [Pg.269]    [Pg.323]    [Pg.119]    [Pg.122]    [Pg.122]    [Pg.123]    [Pg.132]    [Pg.133]    [Pg.138]    [Pg.299]    [Pg.301]    [Pg.321]    [Pg.329]    [Pg.334]    [Pg.338]    [Pg.342]    [Pg.96]    [Pg.98]    [Pg.465]   
See also in sourсe #XX -- [ Pg.226 ]




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Sialidase

Sialidases

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