Sialidase Trypanosoma rangeli

Watts AG, Withers SG (2004) The synthesis of some mechanistic probes for sialic add processing enzymes and the labeling of a sialidase from Trypanosoma rangeli. Can J Chem 82 1581-1588 Watts AG, Oppezzo P, Withers SG, Alzari PM, Buschiazzo A (2006) Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase. J Biol Chem 281 4149-4155... 

M. F. Amaya, A. Buschiazzo, T. Nguyen, and P. M. Alzari, The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase,... 

Buschiazzo, A., Cremona, M. L., Campetella, O., Frasch, A.C.C., and Sanchez, D. O., 1993, Sequence of a Trypanosoma ranged gene closely related to Trypanosoma cruzi trans-sialidase. Mol. Biochem. Parasitol. 62 115-116. 

Galactosyl azides (43 or 44) were separately employed under Afll7-induced cUck coupling with different alkynes (42) and afforded high yield of triazoles 45 and 46. Compound 46b showed maximum Trypanosoma cruzi traws-sialidase (TcTs) inhibitory activity with 37% inhibition, while compound 45b was found as the most powerful inhibitor for in vitro trypanocidal activity against trypomastigote forms of T. cruzi Y strain in hundreds of micrometer range (Scheme 6.13) [29]. 

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