Sialidase Trypanosoma brucei

M. Engstler, R. Schauer, M. A. Ferrero-Garcia, A. J. Parodi, T. Storz-Eckerlin, A. Vasella, C. Witzig, and X. Zhu, N-(4-Nitrophenyl)oxamic Acid and Related N-Acylanilines Are Non-competitive Inhibitors of vibrio cholerae sialidase but do not inhibit trypanosoma cruzi or trypanosoma brucei trans-sialidases, Helv. Chim. Acta., 77 (1994) 1166-1174. 

M. Engstler, G. Reuter, and R. Schauer, Purification and characterization of a novel sialidase found in procycUc culture forms of Trypanosoma brucei. Mol Biochem. Parasitol, 54 (1992) 21-30. 

Engstler, M., Reuter, G., and Schauer, R., 1993, The developmentally regulated trans-sialidase from Trypanosoma brucei sialylates the procyclic acidic repetitive protein. Mol. Biochem. Parasitol. 61 1-14. 

A number of pathogens also have sialidases to aid in pathogenesis or nutrition. Orthomyxoviruses (e.g. influenza) and paramyxoviruses (e.g. mumps, parainfluenza, Newcastle disease, Sendai) have sialidases on their surfaces. Surface sialidase activity is also exhibited by parasites such as Trypanosoma cruzi, T. brucei as well as a number of both pathogenic and non-pathogenic bacteria which may also secrete the enzyme. 

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