Sialidase superfamily

The gp85 glycoproteins are included in the trans-sialidase superfamily, although some members are enzymatically inactive.36 The Tc-85 glycoprotein is specific for the trypomastigote forms37 and is anchored by a GPI with l-<9-hexadecylglycerol.38,39... 

M. J. M. Alves and W. Colli, Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of Trypanosoma cruzi with host structures, in B. A. Burleigh and D. Soldati-Favre, (Eds.), Molecular Mechanisms of Parasite Invasion, 47 pp. 58-96. 

Roggentin, P., Schauer, R., Hoyer, L.L., and Vimr, E.R. (1993) The sialidase superfamily and its spread by horizontal gene transfer. Molecular Microbiology, 9, 915-921. 

Figure 2. The sialidase superfamily (a) Influenza virus neuraminidase tetramer, (b) the small sialidases from S. typhimurium and (c) M. viridifaciens, (d) the side view of the large M. viridifaciens sialidase, (e) V. cholerae sialidase. The inhibitor Neu5Ac2en is shown bound in several active sites and galactose is also shown in the large M. viridifaciens sialidase. The isolated grey spheres represent divalent ions that play a key structural role in influenza and V. cholerae sialidase, and are an absolute requirement for activity.

Weston D, Patel B, Van Voorhis WC (1999) Virulence in Xrypanosoma cruzi infection correlates with the expression of a distinct family of sialidase superfamily genes. Mol Biochem Parasitol 98 105-16. 

Figure 1. Dendrogram of sialidase sequences showing the large sequence variation of this superfamily. HN = hemagglutinin-neuraminidase. Percentage identity is shown to the left.

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