Sialidase catalytic mechanism

Amaya ME, Watts AG, Damager 1, Wehenkel A, Nguyen T, Buschiazzo A, Paris G, Frasch AC, Withers SG, Alzari PM (2004) Structural insights into the catalytic mechanism of Trypanosoma cmzi tran.s-sialidase. Structure 12 775-784... [Pg.145]

M. F. Amaya, A. G. Watts, I. Damager, A. Wehenkel, T. Nguyen, A. Buschiazzo, G. Paris, A. C. C. Frasch, S. G. Withers, and P. M. Alzari, Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase, Structure, 12 (2004) 775-784. [Pg.364]

M. Ribeirao, V. L. Pereira-Chioccola, D. Eichinger, M. M. Rodrigues, and S. Schenkman, Temperature differences for frans-glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans-sialidase, Glycobiology, 1 (1997) 1237-1246. [Pg.364]

Scheme 8 Catalytic mechanism of a sialidase or a frans-sialidase.

Another unusual glycosidase mechanism classified is encountered in family 4, which requires a unique NAD" and Mn " " assisted catalysis. Those enzymes do not follow the classical double-displacement mechanism but act through multiple catalytic steps involving oxidation-elimination-addition and reduction reactions. Other interesting examples can also be found in the case of trans-sialidases and a-glucan lyases. ... [Pg.208]

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