Sialic Acid Substructural Specificities for Siglecs

FIGURE 18.2 Interactions of the a(2- 3)-linked sialyllactose in the binding site of siaload-hesin [37]. Leu, leucine Ser, serine. 

Studies of sialoadhesin and sialoside interactions by NMR provided evidence that the molecular interactions characterized in crystals also occur in solution [39], Although the binding between natural sialosides and siglecs is relatively weak, increased binding affinity has been seen for sialoadhesin, MAG, and CD22 using 

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