Shear stress signalling proteins

Evidence suggests that resveratrol may protect against atherosclerosis by enhancing endothelium integrity through the inhibition of protein kinase C (PKC)-mediated signaling [62]. However, resveratrol was also shown to inhibit protein kinase D, a member of the PKC family, but did not affect other PKC isoforms [63, 64]. Furthermore, effects observed in bovine pulmonary artery endothelial cells subjected to stimulated arterial shear stress were also shown to be unrelated to PKC [65]. 

Berk, B.C. et al.. Protein kinases as mediators of fluid shear stress stimulated signal transduction in endothelial cells a hypothesis for calcium-dependent and calcium-independent events activated by flow, /. Biomech., 28,1439,1995. 

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