Sharp, Phil

Fig. 1-9. Discover " of the absorption edge. The curve shown is for the experiment of Fig. 1-7 with iron and aluminum as the absorbers and elements of increasing atomic number as samples. In this region of the spectrum, absorption by aluminum increases uniformly with X. Iron shows the sharp drop at its K edge. (After Barkla and Sadler, Phil. Mag. [6], 17, 739.)...

Phil Sharp and Leonard Guarente showed that at least four transcription factors are required in addition to polymerase II for initiation from the major late promoter of adenovirus. In vitro studies indicate that these factors assemble in an orderly fashion (see fig. 28.12b). First the TFIID complex binds to the TATA box. Sequential binding of TFIIA, TFIIB, RNA polymerase II, and TFIIE follow. It is believed that this multifactor complex functions for a large number of eukaryotic promoters that contain TATA boxes. 

K. Zeng and D. Rowcliffe, Analysis of Penetration Curves Produced by Sharp Indentation on Ceramic Materials, Phil. Mag. A, 74 (5) 1107 1116 (1996). 

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