Sex steroids

Fig. 1. Chemical stmcture of naturally occurring and synthetic sex steroids used in commercial anabolic steroid implant preparations.

The area of nonsteroidal antiestrogens along with other classes of nonsteroidal antagonists of sex-steroid hormone action has been reviewed to 1986, and these compounds have been grouped by chemical stmcture as a basis of classification rather than any biochemical or biological test system utilized to assess antagonist activity (46). 

Few studies have been conducted on other invertebrate taxa but pentach-lorophenol exposure has been shown to affect daphnid reproductive capacity and sex steroid hormone metabolism and a high incidence of intersex has been observed in harpacticoid copepods near an Edinburgh sewage outfall. " ... 

Testosterone, the principal male sex steroid hormone, is synthesized in five steps from cholesterol, as shown below. In the last step, five isozymes catalyze the 17/3-hydroxysteroid dehydrogenase reactions that interconvert 4-androstenedione and testosterone. Defects in the synthesis or action of testosterone can impair the development of the male phenotype during embryogenesis and cause the disorders of human sexuality termed male pseudohermaphroditism. Specifically, mutations in isozyme 3 of the 17/3-hydroxysteroid dehydrogenase in the fetal testis impair the for-... 

Sex Steroid Receptors Andr ogen Receptor, Estrogen Receptors, Progesterone Receptor... 

Selective Sex Steroid Receptor Modulators Receptor Modulators... 

Sex Steroid Receptors Androgen Receptors, Estrogen Receptors, Pregesterone Receptor... 

Sex Steroid Receptors protein, from which several peptides are generated by... 

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