Sestamibi, MIBI, cardiolite

Several gamma-emitting compounds have been synthesized, vahdated, and characterized as sensitive probes for Pgp and MRPl functional activity. Most of these compounds are cationic and modestly hydrophobic similar to the chemotherapeutic agents in the MDR phenotype. The radiopharmaceutical hexakis(2-methoxy-isobutyl-isonitrile)technetium-99m commonly known as [ Tc]Sestamibi or [ Tc]MIBI (Cardiolite ) was the first imaging agent recognized as transport substrate of Pgp and the most widely used in clinical and pre-clinical studies for functional evaluation of MDR [53]. 

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