Sesquiterpenoid carbazole alkaloids

Examining the structures of the sesquiterpenoid carbazole alkaloids, tubingensins A (379), B (380), aflavazole (381), and dihydrotubingensins A (382) and B (383), it is likely that they are biogenetically related, and could have originated from a common intermediate, nominine (448) (394). This hypothesis was supported by the isolation of nominine (448) and 20,25-dihydrooxyaflavinine (452) from the sclerotia of the same Aspergillus spp. (347). 

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