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Serotonin receptors sequence homology

Key Words G Protein-coupled receptors serotonin receptors rhodopsin sequence homology molecular models protein structure. [Pg.39]

In addition to its receptors, serotonin has transporter molecules and there are alkaloids that interfere with the transport and uptake process. DNA s for serotonin transporters of rat leukemia cells have been cloned and sequenced. One of them has a 653 residue protein with 12-13 transmembrane domains. Interestingly they show considerable homology with transporters of some other transmitter substances and are sensitive to cocaine, reserpine and several other alkaloids [229,230,231,232]. Thus the inhibitory action of serotonin can be reduced not only by substances that act on its receptor but also by substances that hinder its access to the receptor [233]. [Pg.22]

See other pages where Serotonin receptors sequence homology is mentioned: [Pg.241]    [Pg.271]    [Pg.1785]    [Pg.75]    [Pg.18]    [Pg.284]    [Pg.157]    [Pg.872]    [Pg.851]    [Pg.606]    [Pg.22]    [Pg.106]    [Pg.142]    [Pg.314]    [Pg.516]    [Pg.1502]    [Pg.426]    [Pg.251]    [Pg.117]   
See also in sourсe #XX -- [ Pg.420 ]



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