Ser-CCLl

A recent, illustrative example from Okamoto et al. of the extensive applicability of native chemical ligation toward the study of protein stmcture and function is the total chemical synthesis of the glycosylated and non-glycosylated forms of the 73-amino acid chemokine protein CCLl and a 74-amino acid, N-teiminally extended variant, Ser-CCLl [29], The construction of these chemokines was accomplished using a convergent, three-component iterative native chemical Uga-tion approach (see Scheme 4 for a representative example), with the glycosylated... 

Okamoto R, Mandal K, Ling M, Luster AD, Kajihara Y, Kent SBH (2014) Total chemical synthesis and biological activities of glycosylated and non-glycosylated forms of the chemokines CCLl and Ser-CCLl. Angew Chem Int Ed 53 5188-5193... 

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