Sepulchrates application

Thus, the application of the ligand field model [178] in combination with the strain energy minimization model [230] makes it possible to calculate with high accuracy the geometrical parameters of sepulchrate and sarcophaginate frameworks. 

Startg. m. refluxed 3hrs. withNa-methoxide in methanol (lS,4S,7R)-7-tosyloxy-3-oxa-6-azabicyclo[2.2.1]heptane. Y 93%, - This ring closure appears to be generally applicable to the synthesis of chiral norbornane skeletons containing heteroatoms at positions 3 and 6. Also diastereoisomer s. J. Cleophax, S. D. Gero, and A. M. Sepulchre, Carbohyd. Res. 7, 505 (1968). 

Another way to achieve indirect chemical reduction in solution is represented by the use of organometallic complexes (e g., cobalt(lll) sepul-chrate trichloride). Often also redox partners and sometimes NAD(P)H are included in the reaction mixtures along with mediators [231, 232]. For example, application of a platinum wire working electrode supported the hydroxylation of lairric acid by recombinant CYP4A1 in the presence of rat CPR and cobalt(lll) sepulchrate trichloride in solution. The product formation rate obtained was comparable to that obtained with NADPH... 

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