Septic shock terlipressin

The use of vasopressin and terlipressin for the management of septic shock has been reviewed a maximum dose of 0.04 U/minute is recommended (5). Vasopressin 0.23 U/minute in patients with hepatorenal syndrome did not appear to be associated with the adverse effects that occur at the lower doses that are used to treat other critically ill patients (6). 

Delmas A, Leone M, Rousseau S, Albanese J, Martin C. Clinical review vasopressin and terlipressin in septic shock patients. Crit Care 2005 9 212-22. 

Fellahi JL, Benard P, Daccache G, Mourgeon E, Gerard JL. Vasodilatory septic shock refractory to catecholamines is there a role for terlipressin Ann Fr Anesth Reanim 2003 22 631 1. 

Terlipressin, a prodrug converted into lysine vasopressin, has been used recently in septic shock patients." This drug has a half-hfe of 6 hours and acts via vascular receptors aud reual tubular V2 receptors. In one report, terlipressin 1 mg was given intravenously to 15 patients with norepinephrine-resistant septic shock."" Terhpressin was shown to increase MAP at 30 minutes, which lasted for 24 hours. Despite a decrease in cardiac output, terlipressin increased gastric mucosal perfusion, urine output, and creatinine clearance. These preliminary findings suggest that a clinical trial should be conducted that evaluates mortality, in addition to hemodynamic effects. 

MorelU A, Rocco M, Conti G, et al. Effects of terlipressin on systemic and regional haemodynamics in catecholamine-treated hyperkinetic septic shock. Intensive Care Med 2004 30 597-604. 

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See also in sourсe #XX -- [ ]

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