Sepsis and Cytokines Current Status

Pro- and Anti-Inelammatory Cytokines and Circulating Natural Antagonists [Pg.59]

IL-1 (17.5) Monocyte/macrophage, lymphocyte, neutrophil, endothelium, fibroblast keratinocyte Activation of T cells, B cells, natural killer cells, osteoblasts, and endothelium. Induces fever, sleep, anorexia, ACTH release, hepatic acute phase protein synthesis and HSPs. Leads to myocardial depression, hypercoagulability, hypotension/sbock, and death. Simulates production of TNF, IL-6, and IL-8 and stress hormone release. Suppression of cytochrome P-450, thyro-globulin, and lipoprotein synthesis. Procoagulant activity. Antiviral activity. [Pg.59]

IL-8 (8) Monocyte/macrophage, lymphocyte, fibroblast, endothelium, keratinocyte Recruitment and activation of neutrophils, chemotactic for lymphocytes, angiogenesis. [Pg.59]

DL-10 (35) T cell, fibroblast Suppression of B- and T-cell proliferation. Inhibition of LPS-induced monocyte IL-1, IL-8, and TNF production. Induction of IL-lra. Suppression of free radical release and NO-dependent microbicidal activity of macrophages. [Pg.59]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...