Separable nonseparable modes

Microdialysate samples have been analyzed using a variety of nonseparation-based analytical techniques including immunoassay, biosensors, and MS [1-4]. The main limitation to the use of these methods is that they are typically restricted to the measurement of a single analyte. For more complex samples, the detection of multiple substances is usually necessary. In this case, the dialysate sample is normally analyzed by conventional chromatographic or electrophoretic separation methods employing optical, electrochemical, or mass spectrometric modes of detection [5]. 

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