Senoxepin synthesis

Amongst natural products, the oxepin structure occurs only in senoxepin 19, a norsesquiterpene lactone of the groundsel Senecio platiphylla its structure has been established by synthesis [8]. Hydrogenated oxepins and oxepanones are often found in natural products, e.g. in the alkaloids strychnine (20, R = H) and brucine (20, R = OCH3), and in the brassinosteroids, e.g. the growth regulator brassinolid 21. 

Amongst natural products, the oxepin structure occurs only in senoxepin (23), a norsesquiterpene lactone of the groundsel Senecio platiphylla its structure has been established by synthesis [10]. 

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