Self-cleavable diene linker

Schmidt and co-workers have also independently developed the self-cleavable diene linker 14 and solid-phase synthesis of the branched hexasaccharide 16 has been achieved (O Scheme 6) [12], The ring-closing metathesis of 15 provided the allyl glycoside 16 from which the allyl protecting group was readily removed by Ir-mediated isomerization followed by hydrolysis. 

Scheme 16.5. A self-cleavable diene linker via tandem ring-closing metathesis.

Scheme 16.6. Synthesis of a branched hexasaccharide using a self-cleavable diene linker.

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See also in sourсe #XX -- [ ]

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