Selenophene chemistry

One of the reasons for the slow development of selenophene chemistry was the lack of convenient procedures for obtaining selenophene, its homologs, and derivatives. However, Gronowitz et al.42 have reported a semilarge-scale synthesis of selenophene (10), which gives about 150-200 g ( 58% yield) of selenophene per day. The procedure is a pyrolytic reaction... 

Although selenophene and certain of its homologs have been known for about 40 years, selenophene chemistry has advanced very slowly, and only a few of the simplest electrophilic substitution reactions of the nucleus were known7,8 when Yur ev and his co-workers started their investigations. The development was hindered, probably, because there were no convenient procedures to obtain selenophene, its homologs, and derivatives. 

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