Selenium and Tellurium Linker Units

Building on the many examples of thioether linker units, larger numbers of linker units have been reported that utilize the related reactivity profiles of selenium and tellurium compo-nents to achieve multifunctional cleavage. Such linkers tend to be straight- 

LINKER STRATEGIES IN MODERN SOLID-PHASE ORGANIC SYNTHESIS 

Beyond common oxidative cleavage, nucleophilic cleavage from selenium and tellurium linkers can also occur. The nucleophilic substitution can be halogenation (Table 1.14, Entries 11 and or an organometaUic such as copper acetylide (Table 1.14, Entry 

Finally, homolytic cleavage via a radical mechanism has also proven a powerful cleavage technique. Such cleavage is traceless and can be mediated by AIBN and tributyltin hydride (Table 1.14, Entry 14) or AlBN/tils(trimethylsilyl)silane (Table 1.14, Entry 15). Tellurium linker units are cleavable via the same mechanisms (Table 1.14, Entry 

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