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Selection of the Chromatographic Conditions

After the screening of different chiral stationary phases and modifiers (for a review of screening methods please refer to the work of Wewers [29]), the best separation conditions were obtained using the chiral stationary phase (CSP) Chi-ralcel OD 20pm. An organic modifier, isopropanol (IPA), was used to increase the polarity of the eluent in order to get an acceptable retention of the two enantiomers. [Pg.259]

Organic modifiers tend to increase the polarity of the eluent and are perfectly miscible with CO2. The situation is identical to what can be observed with a liquid eluent under the same conditions retention decreases when the percentage of IPA increases. [Pg.259]

The process daily throughput is linked to both the injected amount per run and the time between two successive injections. This time has to be minimized using stacked injections in order to optimize the process productivity and further decrease the eluent consumption. Minimum time between two successive injections corresponds to the time needed for eluting the two enantiomer peaks. Under the selected conditions, this time was equal to 100 s. [Pg.261]


Snyder s classification of solvent properties is important in the selection of the chromatographic conditions and the optimization of the chromatographic processes. [Pg.95]

This example corroborates the above statement that analyte compounds can be separated by several different methods. In many cases, the sample matrix will determine the selection of the chromatographic conditions. [Pg.405]


See other pages where Selection of the Chromatographic Conditions is mentioned: [Pg.259]    [Pg.134]   


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