Selection of factors for other analytical methods

All analytical methods involve some kind of sample preparation and thus the type of factors selected for a HPLC method as shown in Table 5.2 are similar for all methods. However, different stages in the preparation will be more critical for some methods. For instance, derivatisation will be more common for gas chromatography methods and hence more critical. 

Other factors, particularly instrumental controls and settings, which influence ruggedness will vary widely from method to method. Table 5.3 provides a summary of some likely factors for various analytical methods. 

It can be seen that similar sample preparation factors are selected from method to method, but relevant instrument factors are much more varied from technique to technique. 

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