Selected reaction monitoring distribution studies

The selected items give a total of 600 possible combinations. Of these, 296 systems were studied in experimental runs, and of these, 162 afforded the Fischer indole reaction. The other systems failed. The successful systems were used for PLS modelling. The reaction were monitored by gas chromatography for 48 h after which time the increase in yield was insignificant. No isomerization occurred. The isomer distribution was determined from the gas chromatograms. The response used for PLS modelling was the regioisometrc excess, RE = Amount of major isomer — Amount of minor isomer. 

Since commercially available monolithic supports for environmental catalysts are not suitable for this class of applications, as explained above, in the early studies homemade high conductivity structured catalysts were prepared by assembling washcoated slabs of aluminium or stainless steel to form plate-type catalytic cartridges, which were also equipped with thermowells for sliding thermocouples in order to monitor the temperature distributions. The washcoat consisted of Pd (3%w/w) on y-Al203, and the catalysts were tested in the oxidation of CO, selected as a model exothermic reaction. 

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