Selected Examples of Acylation Reactions with Interest for the Pharmaceutical Industry

3 Selected Examples of Acylation Reactions with Interest for the Pharmaceutical Industry 

A selection of KR and DKR of amines is presented from a myriad of examples described in the literature. In this section we have focused on the selection of biotransformations with a variety of amine cores including primary and secondary amines and amino alcohols, leading to the recovery of the final products in excellent enantiomeric excess through KR and DKR reactions. The possibility of scaling up the 

9 ENANTIOSELECTIVE ACYLATION OF ALCOHOL AND AMINE REACTIONS IN ORGANIC SYNTHESIS 

DKR of racemic amines for the synthesis of norsertraline and (/ )-rasagiline mesylate. 

Chemoenzymatic synthesis of (S)-dapoxetine through enantioselective acetylation of an 0-protected amino alcohol precursor with CAL-A. 

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