Seizure disorders tiagabine

Biraben A, Beaussart M, Josien E, Pestre M, Savet JF, Schaff JL, Tourniaire D, Sevestre M, Renault-Djouadi J. Comparison of twice- and three times daily tiagabine for the adjunctive treatment of partial seizures in refractory patients with epilepsy an open label, randomised, parallel-group study. Epileptic Disord 2001 3(2) 91-100. 

Observational studies Almost 2000 patients have been recruited in an open prospective study in which tiagabine was added to a previous unsatisfactory antiepileptic treatment in patients with partial seizures [288 ]. At the second month of treatment, adverse effects were reported by 13% of patients and after 4 months by 8.6%. The most frequent were somno-lence/fatigue, headache/nausea, and anxiety/ mood disorders. No serious adverse events were reported. 

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