Section L - Respiration and energy

The cycle oxidizes pyruvate (formed during the glycolytic breakdown of glucose) to C02 and H20, with the concomitant production of energy. Acetyl CoA from fatty acid breakdown and amino acid degradation products are also oxidized. In addition, the cycle has a role in producing precursors for biosynthetic pathways. 

The citric acid cycle occurs within the mitochondria of eukaryotes and the cytosol of prokaryotes. 

Production of citrate from oxaloacetate and acetyl CoA (catalyzed by citrate synthase). 

Oxidation of isocitrate to a-ketoglutarate (catalyzed by isocitrate dehydrogenase the reaction requires NAD+). 

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