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Second-generation retrosynthetic analysis

Scheme 18.11 Comparison of the first- and second-generation retrosynthetic analysis of the bicyclic [3.1.0]proline core. Scheme 18.11 Comparison of the first- and second-generation retrosynthetic analysis of the bicyclic [3.1.0]proline core.
Scheme 16. Retrosynthetic analysis of brevetoxin B (1) the second-generation approach. Scheme 16. Retrosynthetic analysis of brevetoxin B (1) the second-generation approach.
This is the moment to consider the availability of the TMs of the second-generation TM 2.2a and TM 2.2h. Assuming a Grignard reaction in the synthetic direction, cyclohexyl-bromide is needed. On the first glance this immediate precursor of Grignard reagent TM 2.2b is more easily available than cyclohexyl methyl ketone TM 2.2a (Scheme 2.3). The two-step retrosynthetic analysis of TM 2.2b results in phenol, a commodity from the petrochemical industry. Its hydrogenation produces cyclohexanol, which is brominated under standard conditions. [Pg.23]

See other pages where Second-generation retrosynthetic analysis is mentioned: [Pg.130]    [Pg.130]    [Pg.4]    [Pg.827]    [Pg.50]    [Pg.206]    [Pg.349]    [Pg.19]    [Pg.29]    [Pg.20]   


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Analysis retrosynthetic

Retrosynthetic

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