Second-generation effects fetotoxicity

Second-generation effects Fetotoxicity Heparin has been shown to cause osteopenia in adults, but to date there is no data on an association between heparin and fractures in preterm neonates. A recent report described a preterm infant who received unfractionated heparin for 3 weeks to freat an arterial thrombus. Later X-rays identified multiple fractures that were not present prior to heparin therapy, suggesting a correlation between the dose and duration of therapy and the fractures [20 ]. 

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