6,7-Secoagroclavine synthesis

Secoagroclavine Synthesis of the versatile intermediate 4-(sulfonyl-methyl)indole from 4-oxo-4,5,6,7-tetrahydioindole for the formal total synthesis [28]... 

Synthesis of the 1-methoxy analogue of ( )-6,7-secoagroclavine 226 and its des-methyl derivative (227) have been developed from 2-nitrotoluene, proceeding through 1-methoxyindole in nine steps with an overall yield of 20% (86CPB677). 

An alternative synthesis constitutes yet another synthesis of ( )-6,7-secoagroclavine... 

Synthesis of 6,7-Secoagroclavines, Chanoclmine /, Isochmoclavine /, Norchanocla/ine I, Chanoclavine II, Norchanoclavine //, and Their Enantiomers... 

The acetylenic indoles 202 were partially saturated over the Lindlar catalyst to 203, which was transformed previously to secoagroclavine by Somei etal. (82). Thus, these reaction conditions could provide a promising opportunity for the synthesis of many ergoline alkaloids. 

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