1 ,2 seco -Nucleosides synthesis

In this chapter, an attempt has been made to illustrate the utility of L-ascorbic and D-isoascorbic as sources of chirons in organic synthesis. Although the V,T-seco-nucleosides and their derivatives have not shown significant activity, our goal is to develop methods that bypass requirements for phosphorylation and to generate T-seco and other nucleotides intracellularly. 

P. Vemishetti, R.W. Leiby, E. Abushanab, and R.P. Panzica, A practical synthesis of ethyl l,2,4-triazole-3-carboxylate and its use in the formation of chiral V,2 -seco-nucleosides of ribovirin, J. Heterocycl. Chem. 25 651 (1988). 

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