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SE R RS of Biomolecules

In the remainder of this chapter we review the applications of SE(R)RS in studies of biomolecules at electrode surfaces. We review SE(R)RS as applied in bioelectrochemistry, concentrating attention on studies where the interfacial potential is under direct electrochemical control. In general, and for the sake of brevity, we exclude any detailed discussion of SE(R)RS studies of biomolecules at colloidal nanoparticles where the interfacial potential is undefined for accounts of these studies the reader is directed to some recent reviews [209-214]. [Pg.292]


It is appropriate to conclude this part of the chapter, before going on to review the literature on SE(R)RS of biomolecules at electrode surfaces, by briefly describing tip-enhanced Raman spectroscopy (TERS) since this rapidly developing technique offers the potential for studies at molecular resolution. In TERS a metal nanoparticle or metalized tip (usually Ag or Au) with an apex diameter of about 25 nm is illuminated by a laser as it is scanned across the surface (Figure 6.14). The tip is used to locally amplify and confine the electromagnetic field, in effect creating a local hotspot which can be scanned across the surface. The first examples of this approach were reported in 2000 [193-195]. Since then the approach has been... [Pg.291]

This book chapter will explore the ability of SE(R)RS to detect multiple analytes in a mixture, that is, its ability to multiplex. The detection of DNA will be used as the focus for this discussion however the capabilities of SE(R)RS can be easily extended to any biomolecule, or indeed, any mixture of analytes with distinct spectral fingerprints. [Pg.353]


See other pages where SE R RS of Biomolecules is mentioned: [Pg.292]    [Pg.293]    [Pg.295]    [Pg.299]    [Pg.301]    [Pg.305]    [Pg.307]    [Pg.309]    [Pg.311]    [Pg.313]    [Pg.292]    [Pg.293]    [Pg.295]    [Pg.299]    [Pg.301]    [Pg.305]    [Pg.307]    [Pg.309]    [Pg.311]    [Pg.313]    [Pg.307]    [Pg.315]    [Pg.316]    [Pg.215]   


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Biomolecule

Biomolecules

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