ScyZZo-Inositol

Procedure 2 Glycosynthase-assisted Synthesis of Glycosylated scyZZo-Inositols... 

ATP + 1-amino-1-deoxy-scyZZo-inositol = ADP -i- 1-amino-1-deoxy-scyZZo-in-ositol 4-phosphate... 

ADP -I- 1-amino-1-deoxy-scyZZo-inositol 4-phosphate <1> (<1> scyllo-inosamine-phosphate [1]) [1, 2]... 

Examples myo-Inositol 1,3,5-Triamino-1,3,5-trideoxy-scyZZo-inositol... 

An optically inactive isomer, 2-deoxy-myo-inositol (deoxy-scyZZo-inositol) (scylloqneTcitol (7)), m.p. 233-235 , was synthesized by the catalytic reduction of m2/o-inosose-2 in the presence of mineral acid (56) (Fig. 1). Catalytic reduction of inososes or their oximes in mineral acid appears to be a general way for preparing monodeoxyinositols (57a, 6). 

Since mi/o-inositol had previously been limited to configurations (II) and (V) (p. 280), it must have configuration (V) scyZZo-inositol, an epimer of... 

Some phosphate esters of m /o-inositol have been prepared by the action of phytase on phytic acid 80 H6)y in order to arrive at a better understanding of the structure of the biologically important phytic acid. The structures of these esters are not known. Iselin 117) has prepared myoinositol 2-phosphate and scyZZo-inositol monophosphate via the penta-acetates derived from the reduction of penta-O-acetyl-myo-inosose-2. The myo-inositol derivative does not have the biological activity toward microorganisms that the free inositol has. 

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