Screen target-observe

A clear correlation has been observed between limiting surface tension ycmc and surfactant performance in water-in-C02 microemulsions, as measured by the phase transition pressure Ptnms- These results have important implications for the rational design of C02-philic surfactants. Studies of aqueous solutions are relatively easy to carry out, and surface tension measurements can be used to screen target compounds expected to exhibit enhanced activity in CO2. Therefore, potential surfactant candidates can be identified before making time-consuming phase stability measurements in high-pressure CO2. 

FIGURE 7.6 Targeted metabolite screening procedure, showing a flowchart that could be followed to determine whether to report a potential metabolite observed in a sample assay. (Source Adapted from Wainhaus, S. et al., Am. Drug Dis., 2007, 2, 6. With permission.)... 

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