Scope of the Nucleophilic Addition to Enals

In 2002 the same research group extended this methodology to electron-rich benzenes with excellent results [16]. 

Several research groups have developed Michael reactions with different heterocycles that contains an easily enohzable position. For example, Melchiorre 

Based on these pioneering reports, several groups have developed cascade reactions using as a key step the addition of nitroalkane derivatives to enals [37], 

Cid and Ruano reported that aryl-acetonitriles bearing an electron-withdrawing group at the ortho- or poro-position could serve as suitable nucleophiles in organocatalytic Michael reactions with enals [39]. The reaction proceeded with good yields and good enantioselectivities, albeit with low 

Several other groups have used similar reactions, employing different sulfone derivatives. For example, Rios and Vesely developed the 1-fluoro-l-nitrophenylsulfonylmethane addition to enals [47], promoted by catalyst 27. The final adducts were obtained in good yields and enantioselectivities but low diastereoselectivities. 

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