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Schlittler-Muller

The Schlittler-Muller variation of the Pomeranz-Fritsch reaction involves reaction of diethoxyethanal 17 with benzylamine 16 to prepare the desired imine 18. Intermediate 18 is subsequently cyclised to substituted isoquinoline 19. The advantage here lies in the fact that the initial condensation can still take place between an aldehyde and an amine. [Pg.481]

Diazaphenanthrene 53 has been prepared via the Schlittler-Muller variation of the Pomeranz-Fritsch reaction in moderate yield. ... [Pg.485]

W. J. Gensler, Organic Reactions 6,4 Schlittler-Muller Modification ... [Pg.526]

Jackson modification and Schlittler-Muller modification. The Fischer modification involves the treatment of benzalaminoacetal with fuming sulfuric acid, whereas Bobbitt modification produces tetrahydroisoquinoline derivative through the hydrogenation of an imine intermediate in situ to an aminoacetal, which in turn is converted into product by the acid-promoted cyclization and hydrogenation. This modification for tetrahydroisoquinoline is also known as the Pomeranz-Fritsch-Bobbitt cyclization. The Schlittler-Muller modification involves the preparation of benzalaminoacetal from benzyl amines and gly-oxal semiacetal. In addition, this reaction has been extended to prepare other types of aromatic heterocycles, such as thieno[2,3-c] and thieno[3,2-c]pyridines by intromolecular cyclization to thiophene ring. ... [Pg.2257]

This reaction has been modified to different variants, such as the Bobbitt modification, Fischer modification, and the Schlittler-Muller modification. In addition, different acids have been used as the promoters for this reaction. [Pg.2257]

Formation of isoquinolines by the acid-catalyzed cyclization of benzalaminoacetals prepared from aromatic aldehydes and aminoacetal in the Schlittler-Muller modihcation the starting materials are benzyl amines and glyoxal semiacetal ... [Pg.290]

HCA914 E. Schlittler and J. Muller Helv. Chim. Acta, 1948,31,914. 429... [Pg.637]

Schlittler, E., Muller, J. A new modification of the isoquinoline synthesis according to Pomeranz-Fritsch. Helv. Chim. Acta 1948, 31,914-924. [Pg.656]

Muller, J.M., Schlittler, E. and Bein, H.L (1952) Reserpin, der sedative Wirkstoff aus Rauwolfia serpentina Benth. Experientia (Basel) 8 338. [Pg.28]

See other pages where Schlittler-Muller is mentioned: [Pg.481]    [Pg.485]    [Pg.526]    [Pg.358]    [Pg.358]    [Pg.446]    [Pg.492]    [Pg.11]    [Pg.446]    [Pg.481]    [Pg.485]    [Pg.526]    [Pg.358]    [Pg.358]    [Pg.446]    [Pg.492]    [Pg.11]    [Pg.446]    [Pg.474]    [Pg.429]    [Pg.526]    [Pg.62]    [Pg.330]    [Pg.429]    [Pg.108]    [Pg.324]    [Pg.1144]    [Pg.146]    [Pg.6]    [Pg.136]    [Pg.144]    [Pg.32]    [Pg.526]    [Pg.532]    [Pg.2259]    [Pg.143]    [Pg.290]   
See also in sourсe #XX -- [ Pg.481 , Pg.485 ]



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