Schizophrenia nicotinic acid

Schizophrenia There is no evidence to support the use of nicotinic acid in the treatment of schizophrenia as part of what is referred to as orthomolecular... 

Hoffer A, Osmond H, CallbeckMJ, and Kahan 1 (1957) Treatment of schizophrenia with nicotinic acid and nicotinamide. Journal of Clinical and Experimental Psychopathology 18, 131-58. 

Other B vitamins effected are Niacin (nicotinic acid), pantothenic acid, B 2 (cobalamin) and B2 (Riboflavin). Niacin in massive doses is used in the treatment of schizophrenia. A deficiency of this vitamin (also known as B can result in many of the same neurological problems asB0. Pantothenic acid in conjunction with other vitamins aids in many enzymic duties. Deficiencies in Bio lead to easy fatigue, and a thousand other related problems. The last, riboflavin, is affected quite differently. Ethanol seems to cause the body to hoard tfiis vitamin the exchange hardly seems fair, though. 

Nicotinic acid Supplement nicotinamide deficiency, impaired absorption, increased requirements Therapy pellagra, vasomotoric headache, migraine, schizophrenia... 

Other claims for megadoses of nicotinic acid or nicotinamide, such as the claim that abnormalities associated with schizophrenia, Down s syndrome, hyperactivity in children, etc. can be reduced, have so far failed to win general acceptance. Clearly niacin deficiency or dependency can exacerbate some types of mental illness such as depression or dementia. There have been a number of attempts to treat depression with tryptophan or niacin, or both, on the basis that the correction of depressed brain levels of serotonin would be advantageous. However, these have met with only limited success. Schizophrenics have been treated with nicotinic acid on the basis that their synthesis of NAD is impaired in some parts of the brain, and that the formation of hallucinogenic substances such as methylated indoles may be controlled. 

Reaction of the corresponding acid 34, as well as 3-fluoro- and 4-fluoro-2-furoic acids with bicyclic diamines was used for preparation of nicotinic acetylcholine receptor agonists and antagonists with binding affinity to a4p2 receptor subtype, which is target for the treatment of Alzheimer s disease, schizophrenia, major depression, etc., as low as 3 nM [163],... 

---