Scale parenteral drugs

H. E. Hempel, Large scale manufacture of parenterals, Bull. Parenter. Drug Assoc., 30, 88-95 (1976). 

In fact elderly people have a reduced creatinine clearance, often balanced by the decline in creatinine input with a resulting normal serum creatinine. This is clinically important because drugs which are cleared through the kidneys need to be given in scaled down amounts to prevent cumulation and possible toxicity - e.g., gentamicin and other parenteral aminoglycosides, digoxin. 

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