Scale heat transfer limited strategy

Semibatch copolymerization is most often done in an attempt to maintain a reasonably constant copolymer composition when the comonomers are of widely varying reactivities [1]. Semibatching of initiator is often done to maintain temperature control in a heat transfer-limited kettle, and semibatch addition of initiator or chain transfer agent may be used to maintain a desired MWD. Quantitative strategies for semibatching may be developed through empirical experimentation at the bench or pilot scale, or, if accurate mathematical models are available, classical trajectory optimization techniques may be used [2,3]. 

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