Scaffolding asymmetric hydroformylation

The discovery of the bisphospholane scaffold as a new privileged structure for asymmetric induction in alkene hydroformylation has triggered research for new and improved bisphospholane-type ligands. In this context (k,k)-Ph-bpc has been identified as an excellent ligand for asymmetric hydroformylation, which gives state-of-the-art regio- and enantioselectivities... 

Scheme 4.123 Asymmetric hydroformylation with the assistance of a configurationally stable scaffolding ligand.

Jouffroy M, Semeril D, Armspach D, Matt D. Phosphane-phosphite chelators built on a a-cyclodextrin scaffold application in Rh-catalysed asymmetric hydrogenation and hydroformylation. Eur J Org Chem 2013 27 6069-77. 

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