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Scaffold-based discovery library

In addition to libraries derived from carbohydrates (see Chapter 7), a scaffold-based library approach using amino acids and alkaloids was implemented at Discovery Partners International. Quinine... [Pg.25]

The discovery of novel dihydrofolate reductase inhibitors by structure-based library design based on a 5-(dialkylamino)-2,4-diaminopyrimidine scaffold was reported by Wyss et al. [279] (cf Figure 4.5g). On the basis of a diaminopyrimidine core, a virtual... [Pg.96]


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