Sawada reagent

Cyclopropanation reagent. A similar reagent, prepared from EtZnI + CH2I2, [I-CH2-Zn-Et] [33598-72-0] is known as the Sawada Reagent. [P. Knochel, Encyclopedia of Reagents for Organic Synthesis, John Wiley and Sons, Inc., L. A. Paquette, Ed., New York, 1995,4 2473]... 

Advantage over Simmons-Smith is the homogeneity of the reaction and the high yields with enol ethers. (Not true for Sawada Reagent.)... 

In general, it is advisable to perform photochemical labeling in the absence of oxygen (Chapter 4). Occasionally, with the less common reagents, a requirement for the presence of oxygen has been noted, e.g. for the reaction of 4-thio-UMP with ribonuclease (Sawada and Kanbayashi, 1973), and when covalent attachment of dyes occurs during photo-oxidation experiments (Brandt et al., 1974). 

Naritomi H., M. Kanashiro, M. Sasaki, Y. Kuribayashi, T. Sawada, In vivo measurements of intra-and extracellular Na" " and water in the brain and muscle by nuclear magnetic resonance spectroscopy with shift reagent. Biophys. J. 52, 611—616 (1987). 

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