Sarin aging half-time

Based on multiple factors (total dose of atropine required aging half-times of the nerve agent 2 vs. 4 position of the oxime group (—C = N-OH) on the pyridine ring the number of oximes, both experimentally and commercially available, capable of reactivating cholinesterase and the percent of total cholinesterases that the oxime will reactivate) sarin (GB) and VX usually respond best to treatment. Tabun (GA) and cyclohexyl sarin (GF) are less responsive to treatment, and soman (GD) is the most difficult (least responsive) to treat. 

The oxime 2-pralidoxime chloride (2-PAMC1) was administered by slow intravenous infusion to subjects who had received sarin. The half-time for in vivo aging of the sarin-erythrocyte complex seemed to be about 5 h (Sided and Groff, 1974). 

Sarin (GB) Colorless, odorless liquid 2.1 mm Hg 22,000 mg/m Highly volatile 2-24 hrs LCjolOO mg-min/m LD50 skin 1.7 g Rapid onset aging half-time 3-5 hrs... 

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