Sarcosine , structure

Fig. 14. Structure of cyclosporin A where MeBmt = 4-(2-butenyl)-4, A-dimethylthreonine Sar = sarcosine MeLeu = A-methylleucine ...

Dihydro-2//-pyran-5-carbaldehyde (7) was treated with sarcosine ethylester (2) in the presence of sodium ethoxide. What is the structure of the crystalline product Cii/7/rfN03 given its NMR spectra 27 ... 

Cobalt, tetraamminepyrophosphato-structures, 1, 202, 203 Cobalt, tetraammine(sarcosine)-chirality, 1,198 Cobalt, triammine-structure, 1, 8—10 Cobalt, tricarbonato-reactions, 1,22 Cobalt, tricarbonylnitroso-exchange reactions, 1, 290 Cobalt, trichloro-equilibrium constant, 1, 517 Cobalt, trichlorobis(triethylphosphine)-structure, 1, 45... 

Not surprisingly, the diacid 13 and its diamide are waterlogged with 2-4 molecules of HzO from which they are difficult to liberate. Binding experiments in CHC13, a non-competing solvent, revealed that stoichiometric complexes, e.g. 48 were formed with diketopiperazines 40) (Kh 104) and amides such as malonamide. With structures of inadequate hydrogen bonding capacity, such as sarcosine anhydride, com-plexation does not occur. 

Fig. 12 (a) Chemical structure of poly(sarcosine)-b-poly(y-methyl L-glutamate) copolymer. 

Superior passive stabilised diazo compounds are afforded by the diazoamino compounds (triazenes) that arise by reaction of diazonium salts with a variety of secondary amines [114]. Typically, sarcosine (CH3NHCH2COOH), which gives products based on structure 4.114, as well as N-methyltaurine (CH3NHCH2CH2SO3H) and N methylaniline-4 Sulphonic acid,... 

Figure 8 Structure of cyclosporin A. Abu = L-a-aminobutyric acid Bmt = (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine Sar = sarcosine (A-methylglycine).

The structure of bis(sarcosinato)nickel(n)dihydrate, (CH3NHCH2C00)2Ni,2H20, is octahedral with axial water molecules, and NO bonded sarcosinate groups in the equatorial plane.554... 

Structure vs. properties. Few data exist on variants of sarcosinates, with the cocoyl variant being dominant. The lauryl (C12) variant has been prepared and shows a higher CMC and higher surface tension at the CMC than the cocoyl and the surface tension also shows some dependency on pH. 

Fig. 10. Structures of nonribosomally synthesized peptides of bacterial origin (1-6) and fungal origin (7-9). Me, N-methylated peptide boni Orn, ornithine 4-MHA, 4-methyl-3-hydroxyanthranilic acid Aad, aminoadipic acid Aeo, 2-amino-9,10-epoxy-8-oxodecanoic acid D-Hiv, D-hydroxyisovaleric acid Bmt, (4i )-4-[( )-2-butenyl]-4-methyl-L-threonine Abu, a-aminoisobutyric acid Sar, sarcosine. The boxes signify gene products for peptide synthetases composed of modules which activate and process the indicated amino acids...

Peptoid helices are detected in structure-supporting solvents even in relatively short oligomers. Because intramolecular C=0- H-N H-bond formation cannot be the driving force for peptoid secondary structure, the steric influence of the bulky and chiral side chain is likely to provide the required constraint. Interactions between side-chain groups, and between side chains and the carbonyls of the main-chain amides, may add stability to the ordered secondary structure. However, for very short oligomers (34) or peptoids based on N-substituted a-amino acids with a small side chain (35), such as Nala (also termed sarcosine, Sar, 9), complex mixtures of conformers associated with either cis or trans tertiary amide groups have been detected. In addition to the classic CD technique, the contribution of other spectroscopies, such as pulsed ESR (36), may be of value for the 3-D structural validation of peptoid molecules. 

Copolymers of L-proline and sarcosine have been prepared by Fasman and Blout (1961). These were found to exist in two forms, analogous to poly-L-proline. Form I, which is obtained directly from the copolymerization mixture showed anomalous optical rotatory dispersion and relatively low viscosity. On dissolving form I in 2-chloroethanol, form II is obtained which exhibits normal optical rotatory dispersion and relatively high viscosity. Fasman and Blout have suggested that the transition, form I —> form II, involves a conversion of the structure from ds- amide bonds to fmns-amide bonds. 

Figure 1. Chemical structure of (A) actinomycin D (key Thr, threonine Val, valine Pro, proline Sar, sarcosine and MeFal, methylvaline) (B) adriamycin and daunorubicin (C) DHAQ (D) NQO and (E) HAAF.

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